Research	＞Tetsuya Yagi	printout （168ｋ）→
	Main study contents in COE	Electrophysiological analysis of regeneration of nerve tissue and muscle cells
	Representative researcher	Tetsuya Yagi (professor)
	Institution	Graduate School of Engineering
	Key words	Neuron, Brain / vision, Biometry, Photometry, Integrated device
		�T　Study on functional expression of neurons and muscle cells using a multi-electrode array �U　Study on functional expression of neurons and muscle cells using voltage-sensitive dye �V　Study on functional expression of neurons and muscle cells using Ca-sensitive dye
	�T　Study on functional expression of neurons and muscle cells using a multi-electrode array 　　Activity of neurons and muscle cells can be monitored electrically. Neurons give rise to electrical signals with action potentials. These action potentials are measured by the multi-electrode array. We measure differences of electrical activity between normal and transplanted tissue and analyze levels of differentiation and reguneration of transplanted cells and tissues. 　�U　Study on functional expression of neurons and muscle cells using voltage-sensitive dye 　　Electrical activity of neurons and muscle cells is measured by imaging the tissue using voltage-sensitive dye. The dye incorporated into the cell membrane changes fluorescence due to the change of membrane voltage. Therefore, the electrical activity of neurons and muscle cells can be analyzed by monitoring the fluorescence change with a camera. This imaging technique is thought to be useful to measure levels of differentiation and regeneration transplanted neurons and muscle cells. 　�V　Study on functional expression of neurons and muscle cells using Ca-sensitive dye 　　Intracellular calcium is closely related not only to electrical activity of the cell but also to various physiological changes of neurons. Calcium-sensitive dye changes fluorescence by binding with calcium. Therefore, electrical activity of neurons and muscle cells is measured by imaging the tissue using Ca-sensitive dye. This imaging technique is also thought to be useful to measure levels of differentiation and regeneration transplanted neurons and muscle cells. Other study contents of Yagi laboratory ■Study of dynamics of nerve circuit in the cerebral visual area ■Study of transplantation-type artificial visual device for reconstruction of vision ■Study of application for superparallel analog integrated circuit and robot vision Yagi associated page≫

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