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@T@Protein crystallization and structural analysis |
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@@Elucidation of stereostructure is important for the functional analysis
of protein. Generally, protein is crystallized, and the stereostructure
is clarified by X-ray structure analysis. However, high-quality crystallization
is difficult for many proteins, and crystallization of membrane proteins,
which are important for medicine and new drug development, is a subject
of interest.
For proteins difficult to crystallize, Osaka University has originally
developed 1) crystal nucleus generation process by femtosecond laser irradiation,
2) high-quality crystallization process by stirring of solution, and 3)
protein crystal processing by complete solid-state 193 nm laser, and markedly
improved the success rate of structural analysis by application of these
techniques, compared to that using the standard method. In this COE, we
aim at highly precise structural analysis of various proteins. |
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@U@Development of an artificial joint (collaborative study with Dr. Yoshikawa) |
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@@We have succeeded in promoting the entrance of osteocytes into grooves
prepared by laser processing on the artificial joint surface and improving
the strength of contact with bone in collaborative studies with Orthopedics,
Department of Medical Research, for the first time. In this COE, we will
develop superaccurate laser processing and materials for maintenance of
strength of the main body of artificial joints. |
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@V@Tissue processing using complete solid-state ultraviolet laser |
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@@We will establish the superaccurate laser processing step for tissues
and cells using a complete solid-state 193 nm laser of wavelength-converting
crystal CsLiB6010 discovered at Osaka University. This laser generates
highly repetitive laser pulses with a short-pulse width, which excimer
lasers cannot generate, allowing non-heating processing, compared to the
current ArF excimer laser. Using this property, we aim at applying it to
tissue processing steps such as refractive surgery. |
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@W@A pilot study for the development of an all-solid ultraviolet laser
generator and exploration of fields of its application |
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@@On the basis of research results concerning element technologies of
all-solid ultraviolet laser, which was developed as one of NEDO projects
for supporting industrial technologies aimed to uncover the technological
innovations of young investigators, we perform ga pilot study for the
development of an all-solid ultraviolet laser generator and exploration
of fields of its applicationh, intended to develop an all-solid ultraviolet
laser with better characteristics and to apply it to the fields of medicine
and bioscience. In this study, we carry out investigations necessary for
evaluation of organization of a project, and collection of basic data. |
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Other study contents of Mori laboratory |
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‘Development of GaN bulk crystals for photon device
‘Development of novel nonlinear optical crystals
‘Development of novel organic nonlinear optical crystals for generation
of terahertz waves
‘Protein crystallization project@( SOSHOj |
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Mori associated pageβ |
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