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Ⅰ Construction of 3-dimensional artificial tissues consisting of
various cell types |
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Organs and tissues in the body consist of various types of cells, not
a single type, and the cells supply humoral factors such as proteins, hormones,
and cytokines to each other to generate a function of the tissue.
The objective of this study is in vitro construction of 3-dimensional
artificial tissues consisting of multiple cell types, not a single type,
by combination of alternate adsorption method, which provides polymer membranes
at a nano-level, and cells and cell growth factors. 3-dimensional artificial
tissue consisting of various cell types has never been produced, and this
study may become a basic technique in regenerative medicine. |
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ⅡPreparation of organic-inorganic composite materials by alternate soaking
process and application for bone regenerative medicine |
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Hydroxyapatite has been frequently used in bone regeneration,. However,
bovine bone-derived hydroxyapatite is used in general, and its antigenicity
is a concern. Our laboratory has developed an alternate soaking process
that forms hydroxyapatite 100 times faster than the current method, and
reported that hydroxyapatite composite materials with various organic compounds
and metal materials can be easily prepared using this method.
We have reported that agarose gel-hydroxyapatite composite materials are
superior dental materials to the commercial materials, and guglielmi detachable
coil-hydroxyapatite composite is useful for treatment of brain aneurysm.
In this study, organic-inorganic composite materials will be prepared using
the alternate soaking process for the purpose of the development of bone
regenerativeon materials. |
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Ⅲ Development of space-time controlled drug delivery system using nanoparticles
and hollow nanocapsules |
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A drug delivery system that gradually releases a requisite amount of
drug for a specified period at the target place (cells) is very effective
for regenerative medicine, but such a system has not yet been developed.
Our laboratory tries to develop a drug delivery system that is highly capable
of controlling space and time factors in releasing the drug, such as initiation
time, duration, and place of sustained release, by using nanoparticles
and hollow nanocapsules. |
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Other study contents of Akashi laboratory |
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■Development of an anti-retrovirus nanoparticle-based vaccine utilizing
nanoparticles
■Stereoregular template polymerization by layer-by-layer assemblyalternate
■Development of environmental liquid crystalline engineering plastics
using rigid- linear natural substances
■Design and synthesis of functional compounds with molecular-recognition ability
■Nano-coating of hydrogel surfaces with a polymer ultrathin membrane
■Development and application of oil gelating polymers |
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Akashi associated page≫ |
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